期刊
MOLECULAR CRYSTALS AND LIQUID CRYSTALS
卷 434, 期 -, 页码 587-598出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/15421400590957288
关键词
biosensor; chromonics; liquid crystal
We describe director distortions in the nematic liquid crystal (LC) caused by a spherical particle with tangential surface orientation of the director and show that light transmittance through the distorted region is a steep function of the particle's size. The effect allows us to propose a real-time microbial sensor based on a lyotropic chromonic LC (LCLC) that detects and amplifies the presence of immune complexes. A cassette is filled with LCLC, antibody, and antigen-bearing particles. Small and isolated particles cause no macroscopic distortions of the uniformly aligned LCLC. Upon antibody-antigen binding, the growing immune complexes.
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