期刊
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
卷 123, 期 1, 页码 146-152出版社
AMER SOC CLINICAL PATHOLOGY
DOI: 10.1309/PUUXEGXDLH26NXA2
关键词
thalassemia; sickle cell; liver iron concentration; liver biopsy; paraffin; fresh tissue
类别
资金
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR001271] Funding Source: NIH RePORTER
- NCRR NIH HHS [M01RR01271] Funding Source: Medline
In patients with sickle cell disease or beta-thalassemia receiving RBC transfusions for a long period a precise knowledge of the liver iron concentration (LIC) is essential for treatment. Patients underwent LIC and liver pathology assessment by duplicate biopsies in 2 passes from the same local liver site. Fresh tissue cores in trace element free containers and tissues from dissolved paraffin-embedded cores were analyzed. LIC measurements in each of 2 paraffin-embedded cores did not differ significantly (median, 12,455 vs 12,153 mug/g dry weight; n = 29). A significant difference was observed when 1 fresh tissue sample and 1 paraffin-embedded core were analyzed (median, 11,716 vs 12, 864 mug/g dry weight; n = 16; P < .001) with a median disagreement between LIC measurements of 23.0%. We found high agreement in. LICs between liver biopsy specimens processed by the paraffin-embedding technique but overestimation of LICs in comparison with desiccated fresh tissue samples.
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