期刊
JOURNAL OF NATURAL PRODUCTS
卷 68, 期 1, 页码 2-6出版社
AMER CHEMICAL SOC
DOI: 10.1021/np049797o
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资金
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES005853, P01ES010594] Funding Source: NIH RePORTER
- NIEHS NIH HHS [P01 ES010594, P01 ES010594-05, ES R01-05853, ES P01-10594] Funding Source: Medline
A new ladder-frame polyether compound containing five fused ether rings was isolated from laboratory cultures of the marine dinoflagellate Karenia brevis. This compound, named brevenal, and its dimethyl acetal derivative both competitively displace brevetoxin from its binding site in rat brain synaptosomes. Significantly, these compounds are also nontoxic to fish and antagonize the toxic effects of brevetoxins in fish. The structure and biological activity of brevenal, as well as the dimethyl acetal derivative, are described in this paper.
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