期刊
ANALYTICAL SCIENCES
卷 31, 期 4, 页码 257-265出版社
JAPAN SOC ANALYTICAL CHEMISTRY
DOI: 10.2116/analsci.31.257
关键词
Enzymes; fluorescent substrates; fluorescence imaging; medicinal chemistry; chemical biology
资金
- Grants-in-Aid for Scientific Research [15K14937, 15H05371] Funding Source: KAKEN
In this review, we aim to present an overview of how small-molecular fluorescent substrate probes for studying enzymatic functions are developed and how they are used in biological applications, under the following four headings: (1) History of Visual Detection of Enzymatic Activities, (2) Strategies to Design Fluorescent Substrate Probes to Measure Enzymatic Activities, (3) Development of Fluorescent Substrate Probes Suitable for Biological Studies, and (4) Biological Applications of Fluorescent Substrate Probes for Studying Enzymes.
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