期刊
CURRENT PHARMACEUTICAL DESIGN
卷 11, 期 13, 页码 1655-1677出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612053764751
关键词
combretastatins; combretastatin A-4; antimitotic agents; tubulin polymerization; antivascular; drug design; benzophenones; aroylindoles
The design of novel anticancer agents based on the combretastatins, a group of antimitotic agents isolated from the bark of the South African willow tree Combretum caffrum Kuntz, is of considerable contemporary interest. Combretastatin A-4. the most active compound in the group, due to its unique dual features Of antitubulin and antivascular properties. has drawn significant attention of medicinal chemists for the design of analogues as novel antitumor agents. To date. 252 references have been published since 1982 and 187 references have been published since 1998 related to combretastatins research. The 102 references related to chemistry efforts can be classified into three different categories including one-atom. two-atom, and three-atom bridgeheads as linker between two aryl rings of combretastatins. This review will particularly elucidate the rationale and strategic tactics towards the development of novel classes of antimitotic agents, based upon combretastatin A-4 as a promising lead.
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