Effect of wavelength on low-intensity laser irradiation-stimulated cell proliferation in vitro

Background and Objectives: There exist contradictory reports about low-intensity laser light-stimulated cell proliferation. The purpose of this study was to determine the effect of wavelength on proliferation of cultured murine cells. Study Design/Materials and Methods: Proliferation of primary cell cultures was measured after irradiation with varying laser wavelengths. Results: Fibroblasts proliferated faster than endothelial cells in response to laser irradiation. Maximum cell proliferation occurred with 665 and 675 nm light, whereas 810 nm light was inhibitory to fibroblasts. Conclusions: These observations suggest that both wavelength and cell type influence the cell proliferation response to low-intensity laser irradiation. (C) 2005 Wiley-Liss, Inc.