期刊
JOURNAL OF NATURAL PRODUCTS
卷 68, 期 1, 页码 60-63出版社
AMER CHEMICAL SOC
DOI: 10.1021/np040092w
关键词
-
资金
- NATIONAL CANCER INSTITUTE [R35CA044344] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR000954] Funding Source: NIH RePORTER
- NCI NIH HHS [CA 44344-01-12, R01 CA 90111-01-04] Funding Source: Medline
- NCRR NIH HHS [P41RR0954] Funding Source: Medline
A new cycloheptapeptide, phakellistatin 14, was isolated in 8.8 x 10(-7)% yield from Phakellia sp., a marine sponge from Chuuk, Federated States of Micronesia. The structure (1), cyclo-Phe-beta-OMe-Asp-Ala-Met(SO)-Ala-Ile-Pro, was elucidated by 1D and 2D NMR spectral analyses augmented by HRFABMS. The chirality of each amino acid unit was determined to be S using chiral HPLC methods. Phakellistatin 14 showed cancer cell growth inhibitory activity (ED50 5 mug/mL) against the murine lymphocytic leukemia P388 cell line.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据