期刊
JOURNAL OF NATURAL PRODUCTS
卷 68, 期 1, 页码 118-121出版社
AMER CHEMICAL SOC
DOI: 10.1021/np049763g
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资金
- NCI NIH HHS [CA 52955] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [U01CA052955, U19CA052955] Funding Source: NIH RePORTER
Three new C-alkylated iminosugars, batzellasides A (3), B (4), and C (5), along with the known halitoxin (2) polymer were isolated from a Batzella sp. sponge, collected off the west coast of Madagascar. Although this class of azasugars is well known from terrestrial sources, our report represents the first examples of iminosugars from a marine organism. Comparison with the properties of known natural and synthetic iminosugars assisted in the structure determinations. Compounds 3-5 inhibited the growth of Staphylococcus epidermidis with MICs of less than or equal to6.3 mug/mL.
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