期刊
AIDS RESEARCH AND HUMAN RETROVIRUSES
卷 21, 期 1, 页码 43-50出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/aid.2005.21.43
关键词
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资金
- NATIONAL CANCER INSTITUTE [P01CA100730, R01CA063417, Z01BC010252, R21CA093062] Funding Source: NIH RePORTER
- NCI NIH HHS [R21 CA093062, R01 CA063417, P01 CA100730-01, P01 CA100730-02, R21 CA093062-02, R01 CA063417-09] Funding Source: Medline
Cholesterol- rich plasma membrane microdomains are important for entry of many viruses, including retroviruses. Depletion of cholesterol with 2- hydroxypropyl- beta- cyclodextrin inhibits entry of human T cell leukemia virus type I ( HTLV- 1) and HTLV- I envelope pseudotyped lentivirus particles. Using a soluble fusion protein of the HTLV- I surface envelope protein with the immunoglobulin Fc domain, the HTLV- I receptor was found to colocalize with a raft- associated marker and to cluster in specific plasma membrane microdomains. Depletion of cholesterol did not alter receptor binding activity, suggesting a requirement for cholesterol in a postbinding virus entry step.
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