期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 53, 期 1, 页码 67-71出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.53.67
关键词
synthesis; tricyclic alkaloid; 2-pyridone; intramolecular N-acylation; intramolecular C-acylation
A novel and practical preparation of 2-pyridone-containing tricyclic alkaloid derivatives was developed. By regioselective intramolecular N- and C-acylation of 2-(4-aryl-2-pyridon-6-yl)benzoic acid, a pair of structural isomers 2-aryl pyrido[2,1-a]isoindole-4,6-diones and 4-aryl 1-methyl-1H-indeno[1,2-b]-pyridine-2,5-diones, as potential inhibitors of tumor cell proliferation, were prepared respectively.
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