期刊
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
卷 88, 期 1, 页码 15-18出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/j.ijgo.2004.09.017
关键词
L-Arginine; fetal growth restriction; birth weight
Objectivities: To investigate the effects Of L-Arginine in treating! asymmetric fetal growth restriction (FGR). Methods: A total of 66 pregnant women whose fetuses were diagnosed with asymmetric fetal growth restriction were divided into two groups. Group 1 consisted of 36 women who were given routine therapy alone; group 2 consisted of 30 women who were given L-Arginine and routine therapy; and the control group consisted of 30 more women with a normal pregnancy. Results: Before treatment, mean maternal serum levels of NO2-/NO3- were significantly lower in groups 1 and 2 than in the control group (P<0.01). After treatment, maternal serum levels of NO2-/NO3- were considerably higher in group 2 than in group 1 (P<0.01). Mean birth weight was significantly higher in group 2 than in group 1 (P<0.05), but stilt lower in group 2 than in the control group (P<0.01). Conclusions: A deficiency in nitric oxide may play an important role in the development of asymmetric fetal growth restriction. L-Arginine can be used to increase maternal NO2-/NO3- levels and newborn birth weight. (C) 2004 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
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