期刊
NATURE REVIEWS DRUG DISCOVERY
卷 4, 期 1, 页码 59-69出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd1605
关键词
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Adverse drug effects (ADEs) are of great importance in medicine and account for up to 5% of all hospital admissions. ADEs can arise from several mechanisms and a wide range of drugs can cause immune-mediated ADEs (IMADEs). For a drug to elicit an IMADE, it must be both immunogenic ( that is, able to sensitize the immune system) and antigenic ( that is, able to evoke a response from a sensitized immune system). Unlike protein therapeutics, small-molecule drugs ( or xenobiotics) are usually neither immunogenic nor antigenic. IMADEs are therefore the result of complex interactions between drug-metabolizing enzymes, immune sensitization and immune effectors. The genetic aspects of this interplay are discussed in this review.
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