期刊
PLANTA MEDICA
卷 71, 期 1, 页码 72-76出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2005-837754
关键词
Taiwania cryptomerioides; Taxodiaceae; diterpenes; 6-nor-5(6 -> 7)abeo-abietane; cytotoxic activity
Four new 6-nor-5(6-->7)abeo-abietane type diterpenes designated as taiwaniaquinone G, taiwaniaquinone H, taiwamaquinol E and taiwamaquinol F and eight known diterpenes, taiwamaquinones A (5), D (6), E, F (8), and taiwaniaquinols A (9), B, C (11), D (12) were isolated from the bark of Taiwania cryptomerioides. Their Structures were elucidated on the basis of spectroscopic studies. These twelve diterpenes were evaluated for in vitro anti-tumoral cytotoxic activity. The result demonstrated that compounds 5, 6, 8, 9, 11, and 12 bearing an aldehyde group possessed potent cytotoxic activity against KB epidermoid carcinoma cancer cell lines with IC50 values of 6.9, 7.2, 4.4, 8.3, 8.1, and 3.5 muM, respectively.
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