期刊
EMBO REPORTS
卷 6, 期 1, 页码 63-69出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.embor.7400316
关键词
MAPK; ERK5; Bcr/Abl; chronic myeloid leukaemia; survival
资金
- ICREA Funding Source: Custom
It is well established that the mitogen-activated protein kinase ( MAPK) signal is regulated through phosphorylation-dependent activation by the three-tiered MAPK cascade. However, our studies on the interaction of the MAPK ERK5 with the tyrosine kinase c-Abl and its oncogenic variants v-Abl and Bcr/Abl disclosed an alternative aspect of regulation. Independent of the MAPK cascade, Abl kinases were able to regulate the cellular amount of ERK5, at least in part, by stabilizing the protein. The resulting level of ERK5 and its intrinsic basal activity, but not necessarily its activation, were essential and sufficient to increase transformation by v-Abl and to mediate survival of Bcr/Abl-expressing leukaemia cells. These results suggest that the ability to regulate the cellular abundance of ERK5 contributes to the oncogenic potential of Abl kinases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据