期刊
HELVETICA CHIMICA ACTA
卷 88, 期 8, 页码 2235-2249出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.200590157
关键词
-
The title compounds were prepared from valine-derived N-acylated oxazolidin-2-ones, 1-3, 7, 9, by highly diastereoselective ( >= 90%) Mannich reaction (-> 4-6; Scheme 1) or aldol addition ( -> 8 and 10; Scheme 2) of the corresponding Ti- or B-cnolates as the key step. The superiority of the '5,5-diphenyl-4-isopropyl-1,3-oxazolidin-2-one' (DIOZ) was demonstrated, once more, in these reactions and in subsequent transformations leading to various t-Bu-, Boc-, Fmoc-, and Cbz-protected beta(2)-homoamino acid derivatives 11 - 23 (Schemes 3-6). The use of omega-bromo-acyl-oxazolidinones 1-3 as starting materials turned out to open access to a variety of enantiomerically pure trifunctional and cyclic carboxylic-acid derivatives.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据