期刊
CYTOGENETIC AND GENOME RESEARCH
卷 110, 期 1-4, 页码 117-123出版社
KARGER
DOI: 10.1159/000084943
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资金
- NATIONAL LIBRARY OF MEDICINE [P41LM006252] Funding Source: NIH RePORTER
- NLM NIH HHS [2 P41 LM 006252-07A1] Funding Source: Medline
We analyzed potential mechanisms determining chromosomal distributions of the mouse B1 and B2 non-LTR retrotransposons, also known as SINE elements. We report that young B1 and B2 SINEs are underrepresented on chromosome X relative to autosomes, which is consistent with their integration in male germ lines. As the age of the SINE elements progresses, their densities on chromosome X increase relative to autosomal densities, possibly due to differences in ectopic recombination rates between chromosome X and autosomes. Furthermore, unlike young human Alus that tend to be integrated outside Alu-dense regions, young B1 and B2 elements are found mostly in SINE-rich clusters. The B1- or B2-rich clusters are more likely to contain duplicated elements than B1- or B2-poor chromosomal regions. We also present evidence indicating potential association of B I and B2 elements with intrachromosomal segmental duplications. No such association was found with inter-chromosomal duplications. We propose that the accumulation of mouse SINE elements observed in GC-rich regions may be due to the excess of DNA duplications over deletions in gene-rich regions that tend to be GC rich. Copyright (c) 2005 S. Karger AG, Basel.
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