期刊
JOURNAL OF BIOMECHANICS
卷 38, 期 1, 页码 69-75出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2004.03.035
关键词
collagen fibril; stress-deprived; MMP-1; tendon; cells
The purpose of this study was to determine if an association exists between the tensile properties and the collagen fibril diameter distribution in in vitro stress-deprived rat tail tendons. Rat tail tendons were paired into two groups of 21 day stress-deprived and 0 time controls and compared using transmission electron microscopy (n = 6) to measure collagen fibril diameter distribution and density, and mechanical testing (n = 6) to determine ultimate stress and tensile modulus. There was a statistically significant decrease in both ultimate tensile strength (control: 17.95 +/- 3.99 MPa, stress-deprived: 6.79 +/- 3.91 MPa) and tensile modulus (control: 312.8 +/- 89.5 MPa, stress-deprived: 176.0 +/- 52.7 MPa) in the in vitro stress-deprived tendons compared to controls. However, there was no significant difference between control and stress-deprived tendons in the number of fibrils per tendon counted, mean fibril diameter, mean fibril density, or fibril size distribution. The results of this study demonstrate that the decrease in mechanical properties observed in in vitro stress-deprived rat tail tendons is not correlated with the collagen fibril diameter distribution and, therefore, the collagen fibril diameter distribution does not, by itself, dictate the decrease in mechanical properties observed in in vitro stress-deprived rat tail tendons. (C) 2004 Elsevier Ltd. All rights reserved.
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