期刊
NATURE REVIEWS CANCER
卷 6, 期 9, 页码 714-727出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc1913
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The 'magic bullet' concept of specifically targeting cancer cells at the same time as sparing normal tissues is now proven, as several monoclonal antibodies and targeted small-molecule compounds have been approved for cancer treatment. Both antibodies and small-molecule compounds are therefore promising tools for target-protein-based cancer therapy. We discuss and compare the distinctive properties of these two therapeutic strategies so as to provide a better view for the development of new drugs and the future direction of cancer therapy.
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