期刊
GENE THERAPY
卷 13, 期 18, 页码 1313-1319出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.gt.3302838
关键词
non-viral vectors; siRNA; targeted delivery; systemic delivery
类别
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R56AI048851, R01AI048851] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK068556] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI48851] Funding Source: Medline
- NIDDK NIH HHS [DK68556] Funding Source: Medline
Non-viral vectors continue to be an attractive alternative to viral vectors due to their safety, versatility and ease of preparation and scale-up. Over the past few years, investigators have been successful in developing gene carriers that can be targeted to the disease site. Several different delivery vectors for systemic use have been developed by different groups for plasmid DNA and oligonucleotide. Most of them are designed for targeted tumor therapy. The mechanism of inflammatory toxicity, the major toxicity of cationic lipoplex, has been studied and managed. In this review, we focus on the progress made over the last 2 years. We also discuss some future prospects for gene delivery.
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