期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 11, 期 -, 页码 2929-2939出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2022
关键词
immune system; cAMP; Csk; Lck; T cell; lipid raft; review
Spatial organization of signal proteins in specialized cholesterol and glycosphingolipid-enriched microdomains ( lipid rafts) provide specificity in lymphocyte signalling. Src kinases associate with lipid rafts on the basis of their dual acylation in the N-terminus and initiate T cell signalling. The immunomodulatory signal enzyme protein kinase A (PKA) is a serine/threonine kinase that controls a number of processes important for immune activation by phosphorylation of substrates that alters protein-protein interactions or changes the enzymatic activity of target proteins in T cells. PKA substrates involved in immune activation include transcription factors, members of the MAP kinase pathway, phospholipases and the Src kinase Csk. The PKA type I isoenzyme localizes to lipid rafts during T cell activation and modulates directly the proximal events that take place after engagement of the T cell receptor. The most proximal and major target for PKA phosphorylation is the C-terminal Src kinase Csk which initiates a negative signal pathway that fine-tunes the T cell activation process.
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