期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 7, 期 6, 页码 456-462出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1925
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- NIGMS NIH HHS [R01 GM066717, R01 GM066717-04] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM066717] Funding Source: NIH RePORTER
The hypothesis that lipid rafts exist in plasma membranes and have crucial biological functions remains controversial. The lateral heterogeneity of proteins in the plasma membrane is undisputed, but the contribution of cholesterol-dependent lipid assemblies to this complex, non-random organization promotes vigorous debate. In the light of recent studies with model membranes, computational modelling and innovative cell biology, I propose an updated model of lipid rafts that readily accommodates diverse views on plasma-membrane micro-organization.
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