期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 6, 期 1, 页码 8-13出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2005.07.004
关键词
B. licheniformis; cytokines; exopolysaccharide; HSV-2
EPS-1 is a novel extracellular polysaccharide produced by a strain of thermotolerant Bacillus licheniformis, isolated from a shallow marine hot spring of Vulcano Island (Italy). In this paper, antiviral and immunomodulatory effects of EPS-1 were evaluated. It was found that EPS-1 treatment impaired HSV-2 replication in human peripheral blood mononuclear cells (PBMC) but not in WISH cells. Since several cytokines modulate the immune response to viruses, Th1- and Th2-type cytokines were assayed in supernatants of PBMC in different experimental conditions. EPS-1 induced IL-12, IFN-gamma, IFN-alpha, TNF-alpha and IL-18, but not IL-4. Thus, the antiviral effect of EPS-1 on PBMC seems to be related to the pattern of cytokines induced. (c) 2005 Elsevier B.V. All rights reserved.
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