期刊
GENOME BIOLOGY
卷 7, 期 10, 页码 -出版社
BMC
DOI: 10.1186/gb-2006-7-10-r97
关键词
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资金
- NATIONAL CANCER INSTITUTE [R01CA095527] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL007851] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM008759] Funding Source: NIH RePORTER
- NCI NIH HHS [CA095527, R01 CA095527] Funding Source: Medline
- NHLBI NIH HHS [5T32HL07851, T32 HL007851] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008759, T32 GM142607] Funding Source: Medline
Deciphering gene regulatory networks requires the systematic identification of functional cis-acting regulatory elements. We present a suite of web-based bioinformatics tools, called GeneACT http://promoter.colorado.edu, that can rapidly detect evolutionarily conserved transcription factor binding sites or microRNA target sites that are either unique or over-represented in differentially expressed genes from DNA microarray data. GeneACT provides graphic visualization and extraction of common regulatory sequence elements in the promoters and 3'-untranslated regions that are conserved across multiple mammalian species.
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