期刊
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
卷 19, 期 1, 页码 21-27出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.echo.2005.07.010
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资金
- NCRR NIH HHS [M01 RR000069, M01 RR000069-448317] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000069] Funding Source: NIH RePORTER
Background: The myocardial performance index (MPI) correlates with clinical status in adults with idiopathic pulmonary arterial (PA) hypertension (IPAH). This pediatric study used MPI to assess response to bosentan therapy. Methods: The study included 12 children with IPAH and 12 healthy control subjects. MPI was correlated with catheterization data at initiation of bosentan and at a median follow-up of 9 months. Therapy responders were defined by a greater than 20% decrease in mean PA pressure. Results: Right ventricular MPI for patients with IPAH was 0.64 +/- 0.30 versus 0.28 +/- 0.03 in control subjects (P <.01). It had a strong correlation with mean PA pressure (R = 0.94; P <.001). Right ventricular MPI decreased significantly in responders (range 20%-44%, mean 25%) with a 5% increase in nonresponders. Conclusions: Right ventricular MPI in pediatric IPAH correlates with mean PA pressure and response to therapy. This study suggests that this noninvasive Doppler index may be useful to follow up children with IPAH, particularly when tricuspid regurgitation data are insufficient.
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