期刊
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
卷 27, 期 1, 页码 51-57出版社
ELSEVIER
DOI: 10.1016/j.ijantimicag.2005.08.020
关键词
combination; lipid; MRSA; antimicrobial agent; in vitro
The objective of this study was to investigate the in vitro activities of lauric acid and myristylamine in combination with six antimicrobial agents against methicillin-resistant Staphylococcus aureus (MRSA). The combination effect of lipids and antimicrobial agents was evaluated by the checkerboard method to obtain a fractional inhibitory concentration (FIC) index. The effects of lauric acid + gentamicin (GM) and lauric acid + imipenem (IPM) combinations were synergistic against the clinical isolates in 12 combinations. An antagonistic FIC index was observed only with the myristylamine + GM combination. We investigated in detail the antimicrobial activity for two combinations that showed a synergistic effect. The cytotoxicity of lauric acid was not enhanced by the addition of GM and IPM. In time-kill studies, lauric acid + GM and lauric acid + IPM combinations at one-eighth of the minimum inhibitory concentration produced a bacteriostatic effect. (c) 2005 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
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