期刊
NATURE REVIEWS GENETICS
卷 7, 期 1, 页码 45-54出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg1746
关键词
-
资金
- Medical Research Council [G0000502] Funding Source: Medline
- Medical Research Council [G0300662B] Funding Source: researchfish
- MRC [G0000502] Funding Source: UKRI
The efficient repair of DNA double-strand breaks is crucial in safeguarding the genomic integrity of organisms. Responses to double-strand breaks include complex signal-transduction, cell-cycle-checkpoint and repair pathways. Defects in these pathways lead to several human disorders with pleiotropic clinical features. Dissection of the molecular basis that underlies the diverse clinical features is enhancing our understanding of the damage-response mechanisms and their role in development, and might ultimately facilitate treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据