期刊
CURRENT MEDICINAL CHEMISTRY
卷 13, 期 10, 页码 1119-1139出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986706776360905
关键词
epigenetic therapy; histone deacetylase; histone acetyltransferase; HDAC inhibitors; antitumor; apoptosis; chromatin remodeling agents
Chromatin remodeling is a fundamental phenomenon in the life of eukaryotic cells, bearing implications to numerous physiological and pathological phenomena. This review outlines the chemistry of natural and synthetic agents endowed with the ability to interfere with such biological function, with a particular emphasis on histone deacetylase (HDAC) inhibitors. Other aspects covered in this article comprise structure activity relationships (SAR) and modes of action at molecular level, including the description of crystal structures of enzyme-inhibitor complexes.
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