期刊
CURRENT MEDICINAL CHEMISTRY
卷 13, 期 12, 页码 1461-1471出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986706776872934
关键词
glutathione-S-transferases; antitumor agents; drug-resistance; GST inhibitors; prodrugs; apoptosis
Glutathione-S-transferases (GSTs; EC 2.5.1.18), a family of phase II detoxification enzymes, catalyze the conjugation of glutathione with broad substrates including chemotherapeutic agents, and are involved in cell protection against apoptotic signals by inhibiting the stress-signaling cascade mediated by ASKI (Apoptosis signal-regulating kinase)-JNK (c-Jun N-terminal kinase). As GSTs are overexpressed in some malignant tumors, GSTs is a promising therapeutic target. This article reviews the progress in the development of GSTs inhibitors and GSTs activated prodrugs.
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