期刊
BURNS
卷 32, 期 6, 页码 669-677出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.burns.2006.03.015
关键词
collagen nodules; mast cells; hypertrophic scar; porcine; swine; pig; Duroc; myofibroblasts
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R21GM074673] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R21 GM074673] Funding Source: Medline
The etiology and treatment of hypertrophic scar remain puzzles even after decades of research. A significant reason is the lack of an accepted animal model of the process. The female, red Duroc pig model was described long ago. Since the skin of the pig is similar to that of humans, we are attempting to validate this model and found it to be encouraging. In this project we quantified myofibroblasts, mast cells and collagen nodules in the thick scar of the Duroc pig and compared these to the values for human hypertrophic scar. We found the results to be quite similar and so further validated the model. In addition, we observed that soon after wounding an inflammatory cell layer forms. The thickness of the inflammatory layer approaches the thickness of the skin removed as if the remaining dermis knows how much dermis is gone. In deep wounds this inflammatory layer thickens and this thickness is predictive of the thickness of the ultimate scar. (C) 2006 Elsevier Ltd and ISBI. All rights reserved.
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