期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 36, 期 1, 页码 1-8出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2005.10.008
关键词
blood fluke; life cycle; transcriptome; secretion; membrane proteins; Schistosoma
类别
资金
- Wellcome Trust Funding Source: Medline
The lung schistosomulum of Schistosoma mansoni is a validated target of protective immunity elicited in vaccinated mice. To identify genes expressed at this stage we constructed a microarray, representing 3088 contigs and singlets, with cDNA derived from in vitro cultured larvae and used it to screen RNA from seven life-cycle stages. Clustering of genes by expression profile across the life cycle revealed a number of membrane, membrane-associated and secreted proteins up-regulated at the lung stage, that may represent potential immune targets. Two promising secreted molecules have homology to antigens with vaccine and/or immunomodulatory potential in other helminths. (c) 2005 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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