Calculations of double spike isotope dilution results revisited

The use of isotope pattern deconvolution analysis is proposed to simplify the double spiking species-specific isotope dilution result calculations when inter-conversion might occur. A detailed example is given for the determination of Cr(III)/Cr(VI) in yeast by isotope dilution-HPLC-ICPMS. The results are in exact agreeent with the conventional isotope dilution calculations.