期刊
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
卷 21, 期 1, 页码 32-35出版社
WILEY
DOI: 10.1002/gps.1419
关键词
basal ganglia; cognitive functions; magnetic resonance imaging; non-demented elderly; subcortical gray and capsular structures; white matter hyperintensities
资金
- NIA NIH HHS [AG05133] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [P50AG005133] Funding Source: NIH RePORTER
Objective To investigate the relationship between magnetic resonance imaging (NIRI) subcortical gray and capsular (SGCH) and white matter hyperintensities (WMH) and cognitive functions in non-demented community dwelling elderly. Methods The severity of SGCH and WMH on proton density and T2 MR images in 16 subjects was scored using the sermquantitative rating scale of Scheltens et al. (1993). A limited series of cognitive tests selected a priori were then correlated with severity of SGCH and WMH. Results Analysis demonstrated that severity of SGCH was inversely related to performance on the Digit Span (R = -0.64, p < 0.01) and the Stroop Color Word Tests (R = -0.64, p < 0.01). Severity of WMH was related to worsening performance on the Trail Making Test (R = 0.67, p < 0.005). Conclusions These findings indicate that severity of WMH is negatively related to more pure executive cognitive functions, specifically set shifting, while severity of SGCH is inversely related to more basic functions of attention and working memory. Copyright (c) 2005 John Wiley & Sons, Ltd.
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