期刊
ANALYST
卷 131, 期 10, 页码 1075-1078出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b604498k
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资金
- Medical Research Council [MC_qA137293] Funding Source: researchfish
- MRC [MC_qA137293] Funding Source: UKRI
Metabonomic/ metabolomic studies can involve the analysis of large numbers of samples for the detection of biomarkers and confidence in the analytical data, generated by methods such as GC and HPLC-MS, requires active measures on the part of the analyst. However, quality control for complex multi-component samples such as biofluids, where many of the components of interest in the sample are unknown prior to analysis, poses significant problems. Here the repeat analysis of a pooled sample throughout the run, thereby enabling the analysis to be monitored and controlled using targeted inspection of the data and pattern recognition, is advocated as a pragmatic solution to this problem.
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