期刊
BIOLOGICAL CHEMISTRY
卷 387, 期 1, 页码 11-14出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2006.003
关键词
bradykinin; ion channels; nociceptors; pain hypersensitivity; peripheral sensitization; TRPs
资金
- NINDS NIH HHS [K08 NS044139] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [K08NS044139] Funding Source: NIH RePORTER
Pain hypersensitivity after tissue injury and inflammation is contributed to by a reduction in the threshold and an increase in the responsiveness of the peripheral terminals of high-threshold nociceptor neurons, the phenomenon of peripheral sensitization. Bradykinin, acting via G-protein-coupled receptors expressed by the sensory neurons, links to multiple intracellular signaling pathways that in turn interact with voltage-gated and ligand-gated ion channels, changing their properties in such a way as to enhance the response to peripheral stimuli.
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