期刊
IUBMB LIFE
卷 58, 期 9, 页码 508-514出版社
WILEY
DOI: 10.1080/15216540600838232
关键词
interferon; RNase L; antivirus; apoptosis; prostate cancer
资金
- NATIONAL INSTITUTE ON AGING [R21AG025128] Funding Source: NIH RePORTER
- NIA NIH HHS [1 R21 AG025128-01] Funding Source: Medline
2'-5'oligoadenylate-dependent ribonuclease L (RNase L) is one of the key enzymes involved in the function of interferons (IFNs), a family of cytokines participating in innate immunity against viruses and other microbial pathogens. Upon binding with its activator, 5'-phosphorylated, 2'-5' linked oligoadenylates (2-5A), RNase L degrades single-stranded viral and cellular RNAs and thus plays an important role in the antiviral and antiproliferative functions of IFNs. In recent years, evidence has revealed that RNase L displays a broad range of biological roles which are summarized in this review.
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