期刊
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
卷 47, 期 1, 页码 14-23出版社
WILEY
DOI: 10.1111/j.1574-695X.2006.00057.x
关键词
Malassezia; atopic dermatitis; dendritic cell; keratinocyte; inflammatory response
Malassezia spp. are members of the normal cutaneous flora, but are also associated with several cutaneous diseases. Recent studies of the interaction of Malassezia spp. with melanocytes, fibroblasts, keratinocytes and dendritic cells have highlighted their potential to modulate the immune response directed against them. In normal skin they may downregulate the inflammatory response, allowing them to live as commensals. In contrast, in atopic/eczema dermatitis syndrome and psoriasis, they may elicit an inflammatory response that contributes to the maintenance of lesions. Future research may define ways to influence this inflammatory cycle and hence to control or prevent exacerbations of these diseases.
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