期刊
FEMS YEAST RESEARCH
卷 6, 期 4, 页码 513-524出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1567-1364.2006.00071.x
关键词
glycosylation; mannose receptor; glycosylphosphatidylinositol anchor; vaccine; cryptococcosis
资金
- NIAID NIH HHS [R01 AI025780-19, R01 AI025780-17, R01 AI066087-01, R01 AI025780, R01 AI025780-20, R01 AI066087, R01 AI25780, R01 AI37532, R01 AI025780-18] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI066087, R01AI025780, R01AI037532] Funding Source: NIH RePORTER
T-cell-mediated immunity is necessary for effective host defenses against infections caused by Cryptococcus neoformans. Clinical and experimental studies have identified a heterogeneous family of mannoproteins as critical cryptococcal antigens responsible for stimulating T-cell responses. The archetypal mannoprotein has a signal sequence, a functional domain, a serine/threonine-rich region and a site for attachment of a glycosylphosphatidylinositol anchor. Extensive O-mannosylation, which occurs at the serine/threonine region, facilitates recognition by mannose receptors on antigen-presenting cells, particularly dendritic cells. This results in efficient antigen uptake, processing and presentation to T cells. Inhibition of mannose receptors or deglycosylation of mannoproteins profoundly inhibits T-cell responses, demonstrating the crucial contribution of mannosylation to immunogenicity.
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