期刊
FEMS YEAST RESEARCH
卷 6, 期 4, 页码 537-542出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1567-1364.2006.00072.x
关键词
glucuronoxylomannan; GXM; Crytococcus neoformans; fungus; apoptosis; T cells
Cryptococcus neoformans is an opportunistic fungus responsible for life-threatening infections in immunocompromised and occasionally in immunocompetent hosts. The fungus is endowed with several virulence factors such as its capsular polysaccharide, which plays a key role in virulence. The major component of capsular material of C. neoformans is glucuronoxylomannan, a polysaccharide that exhibits potent immunosuppressive properties in vitro and in vivo. Here we describe a new aspect relative to glucuronoxylomannan-induced immunosuppression. In this review we analyze the suppressive effects of glucuronoxylomannan and the mechanisms leading to induction of apoptosis in T cells.
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