期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 6, 期 6, 页码 671-680出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955706777435634
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资金
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR017677] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI056168] Funding Source: NIH RePORTER
- NCRR NIH HHS [RR17677] Funding Source: Medline
- NIAID NIH HHS [AI56168] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Sphingolipids had long been regarded as merely structural components of eukaryotic cellular membranes. Research has discovered sphingolipids to have crucial roles in cellular processes as bioactive molecules. Lately, there has also been an increased interest in sphingolipids and sphingolipid-metabolizing enzymes as mediators of microbial pathogenicity and as potential targets for the development of new therapeutics. This minireview will provide a comprehensive analysis of sphingolipid pathways in mammalian and microbial cells, highlighting their uniqueness and discussing their potential as therapeutic targets for microbial infections.
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