期刊
FEMS YEAST RESEARCH
卷 6, 期 4, 页码 567-573出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1567-1364.2006.00056.x
关键词
Caenorhabditis elegans; Cryptococcus neoformans; Drosophila melanogaster; fungal infection; Galleria mellonella; Toll-pathway
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [K08AI063084] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI63084-01] Funding Source: Medline
Analysis of the molecular mechanisms by which a pathogen interacts with the human host is most commonly performed using a mammalian model of infection. However, several virulence-related genes previously shown to be involved in mammalian infection with Cryptococcus neoformans have also been shown to play a role in the interaction of these pathogens with invertebrates, such as Acanthamoeba castellanii, Caenorhabditis elegans, Dictyostelium discoideum, Drosophila melanogaster and Galleria mellonella. The study of host-pathogen interactions using these model hosts has allowed rapid screening of mutant libraries and can be used for the study of evolutionarily preserved aspects of microbial virulence and host response.
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