期刊
COORDINATION CHEMISTRY REVIEWS
卷 250, 期 11-12, 页码 1286-1293出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2005.11.015
关键词
peroxidase; myoglobin; hemoglobin; reactive nitrogen species; peroxynitrite; nitrogen dioxide
Nitration of tyrosine residues in proteins represents a pathological event that is associated with several human and animal diseases. Besides the classical pathways of formation of reactive nitrogen species (RNS) by NO oxidation, several studies show that heme peroxidases also play an important role in RNS generation. The mechanism of generation of these species has been studied in detail focusing on the nitration of several tyrosine and tryptophan derivatives. Also the O-2-storage and O-2-carrier heme proteins, myoglobin and hemoglobin, can induce RNS formation and promote self-nitration and oxidation. These reactions bear biological relevance and, therefore, the identification of the sites of endogenous modification of these proteins has been carried out by proteomic analysis. (c) 2005 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据