期刊
PHYTOMEDICINE
卷 13, 期 1-2, 页码 119-131出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.phymed.2004.07.006
关键词
Humulus lupulus; pharmacognosy; pharmacology; estrogenic properties
资金
- NCCIH NIH HHS [P50 AT000155, P50 AT00155, P50 AT000155-070001] Funding Source: Medline
- National Center for Complementary & Integrative Health [P50AT000155] Funding Source: NIH RePORTER
As the population ages, there is an ever-increasing need for therapeutic agents that can be used safely and efficaciously to manage symptoms related to postmenopausal estrogen deficiency. Endogenous estrogens, e.g., 17 beta-estradiol, of exogenous mammalian origin, e.g., horses, have long been used to manage such symptoms. There are more than 20 different classes of phytochemicals that have demonstrated affinity for human estrogen receptors in vitro. Some studies on exogenous estrogenic substances of botanical origin (phytoestrogens), such as standardized formulations of plant extracts with in vitro and in vivo estrogenic activity from soy (Glycine max Merill.) and red clover (Trifolium pratense L.), suggest clinical efficacy. Few clinical data for phytoestrogens other than isoflavonoids are available. In an exhaustive review of the literature through 2003, only two clinical trials were identified that were designed to evaluate the effect of hops (Humulus lupulus L.) on symptoms related to menopause. Folkloric, chemical, and biological literature relating primarily to the use of hops for their estrogenic activity, and two human clinical trials, are reviewed. (c) 2005 Elsevier GmbH. All rights reserved.
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