期刊
TOXICOLOGIC PATHOLOGY
卷 34, 期 5, 页码 599-608出版社
SAGE PUBLICATIONS INC
DOI: 10.1080/01926230600865531
关键词
BALT; GALT; immunopathology; lab animal; MALT; morphology; mucosal immune system; NALT
资金
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [N01ES095435] Funding Source: NIH RePORTER
- Intramural NIH HHS Funding Source: Medline
- NIEHS NIH HHS [N01 ES 35513, N01 ES 95435] Funding Source: Medline
The mucosa-associated lymphoid tissue (MALT) initiates immune responses to specific antigens encountered along all mucosal surfaces. MALT inductive sites are secondary immune tissues where antigen sampling occurs and immune responses are initiated. Effector sites, present as diffuse lymphoid tissue along all mucosal surfaces are the sites of IgA transport across the mucosal epithelium. Though there are many differences between inductive sites in various organs, they all contain the same basic compartments-follicles, interfollicular regions, subepithelial dome regions, and follicle-associated epithelium. The morphologic differences between MALT and other secondary lymphoid tissues, between the MALT sites of differing anatomic locations, and species differences among laboratory animals are described. The morphologic changes in MALT associated with aging, route of nutrition, and genetic mutation (i.e., the nude and SCID mutations) are also discussed. MALT tissues comprise the mucosal immune system which can function independently of the systemic immune system and are, therefore, an important and often overlooked aspect of immunopathology.
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