期刊
TOXICOLOGIC PATHOLOGY
卷 34, 期 5, 页码 455-465出版社
SAGE PUBLICATIONS INC
DOI: 10.1080/01926230600867743
关键词
immunopathology; lab animal; marginal zone; morphology; red pulp; spleen; white pulp
资金
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [N01ES095435] Funding Source: NIH RePORTER
- NIEHS NIH HHS [N01 ES 35513, N01 ES 95435] Funding Source: Medline
The spleen is the largest secondary immune organ in the body and is responsible for initiating immune reactions to blood-borne antigens and for filtering the blood of foreign material and old or damaged red blood cells. These functions are carried out by the 2 main compartments of the spleen, the white pulp (including the marginal zone) and the red pulp, which are vastly different in their architecture, vascular organization, and cellular composition. The morphology of these compartments is described and, to a lesser extent, their functions are discussed. The variation between species and effects of aging and genetics on splenic morphology are also discussed.
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