期刊
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
卷 5, 期 6, 页码 629-632出版社
SPRINGERNATURE
DOI: 10.1039/b517734k
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资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI031882, R37AI020201] Funding Source: NIH RePORTER
The M2 ion channel proteins of influenza A and B viruses are essential to viral replication. The two ion channels share a common motif, HXXXW, that is responsible for proton selectivity and activation. The ion channel for the influenza A virus, but not influenza B virus, is inhibited by the antiviral drug amantadine and amantadine-resistant escape mutants form in treated influenza A patients. The studies reviewed suggest that an antiviral compound directed against the conserved motif would be more useful than amantadine in inhibiting viral replication.
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