期刊
TOXICOLOGIC PATHOLOGY
卷 34, 期 6, 页码 708-715出版社
SAGE PUBLICATIONS INC
DOI: 10.1080/01926230600918876
关键词
hepatitis; murine norovirus; immunodeficient mice; dendritic cells; caliciviruses; pneumonia
资金
- NIAID NIH HHS [R01 AI054483, AI007163] Funding Source: Medline
- PHS HHS [U54 A1057160] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI000897, R01AI054483, Z01AI000897, T32AI007163] Funding Source: NIH RePORTER
Murine norovirus (MNV) was recently discovered in Rag2(-/-)/Stat1(-/-) mice in a U.S. medical research facility. Presently, little is known concerning the epidemiology and natural history of this virus. We studied the pathology of naturally occurring MNV infection in 28 immunodeficient mice of several different genotypes (Rag1(-/-)IFN gamma R-/-, OT1 Rag1(-/-) IFN gamma R-/-, OT2 Rag1(-/-)IFN gamma R-/-, Rag1(-/-)/Stat1(-/-), and Rag2(-/-)) that were maintained in two U.S. research facilities. The mice were selected for study because sentinel mice housed in their holding rooms had been identified as positive for MNV-specific antibodies during routine screening for infectious agents. Our data indicate that in certain lines of immunodeficient mice, MNV can establish a disseminated infection that is characteristically associated with inflammation in multiple tissues, including liver (hepatitis), lung (focal interstitial pneumonia) and the peritoneal and pleural cavities. In addition, MNV can establish an asymptomatic infection in the mesenteric lymph nodes of Rag2(-/-) mice. Further studies are needed to determine whether MNV presents a confounding variable in immunological, toxicological and pathological studies in mice naturally infected with MNV.
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