期刊
EXPERT REVIEW OF PROTEOMICS
卷 3, 期 3, 页码 271-281出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14789450.3.3.271
关键词
biomolecular interaction; high-throughput screening; label-free detection; optical biosensor; photonic crystal; proteomics
This review describes a new type of label-free optical biosensor that is inexpensively manufactured from continuous sheets of plastic film and incorporated into standard format microplates to enable highly sensitive, high-throughput detection of small molecules, proteins and cells. The biosensor and associated detection instrumentation are applied to review two fundamental limiting issues for assays in proteomics research and drug discovery: requirement for quantitative measurement of protein concentration and specific activity, and measurements made with complex systems in highly parallel measurements. SRU Biosystems, Inc.'s BIND(TM) label-free detection will address these issues using data examples for hybridoma screening, epitope binning and mapping, small-molecule screening, and cell-based functional assays. The review describes several additional applications that are under development for the system, and the key issues that will drive adoption of the technology over the next 5 years.
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