期刊
BULLETIN OF MATHEMATICAL BIOLOGY
卷 68, 期 1, 页码 99-130出版社
SPRINGER
DOI: 10.1007/s11538-006-9066-z
关键词
time delays; reaction diffusion equations
The incorporation of time delays can greatly affect the behaviour of partial differential equations and dynamical systems. In addition. there is evidence that time delays in gene expression due to transcription and translation play an important role in the dynamics of cellular systems. In this paper, we investigate the effects of incorporating gene expression time delays into a one-dimensional putative reaction diffusion pattern formation mechanism on both stationary domains and domains with spatially uniform exponential growth. While oscillatory behaviour is rare, we find that the time taken to initiate and stabilise patterns increases dramatically as the time delay is increased. In addition, we observe that on rapidly growing domains the time delay can induce a failure of the Turing instability which cannot be predicted by a naive linear analysis of the underlying equations about the homogeneous steady state. The dramatic lag in the induction of patterning, or even its complete absence on occasions, highlights the importance of considering explicit gene expression time delays in models for cellular reaction diffusion patterning.
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