期刊
CELL BIOCHEMISTRY AND BIOPHYSICS
卷 46, 期 1, 页码 79-90出版社
HUMANA PRESS INC
DOI: 10.1385/CBB:46:1:79
关键词
p14(ARF); B23; NPM; nucleoplasmin; ribosomal biogenesis; cancer
资金
- NCI NIH HHS [CA87580, K01 CA087580, R01 CA100302, CA100302] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA100302, K01CA087580] Funding Source: NIH RePORTER
B23 (nucleophosmin/NPM) is a multifunctional protein that recently has been directly implicated in the p53 network by its documented interaction with the p14(ARF)/p19(Arf) tumor suppressor, a major upstream activator of p53. Here we provide an overview of the functional interactions of B23 and ARE We also integrate the current models into a unified picture, showing that B23 is essential for stabilizing and maintaining a basal level of ARF in the nucleolus, whereas increasing levels of ARF after oncogenic stress promotes B23 degradation and interferes with B23 nucleocytoplasmic shuttling. In this way, ARF can be regarded as a parasitic peptide on the B23 molecule, because ARF uses this chaperone for its own survival but also antagonizes normal activities of B23. Finally, the functional significance of the ARF-B23 interaction for tumor development and the prospects for novel cancer therapies are evaluated.
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