期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 30, 期 8, 页码 699-710出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2005.10.002
关键词
monotremes; T cell receptor; gamma/delta; diversity; evolution; marsupial; phylogeny
资金
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR018754] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R25GM060201] Funding Source: NIH RePORTER
- NCRR NIH HHS [1P20RR18754] Funding Source: Medline
- NIGMS NIH HHS [I-R25-GM60201] Funding Source: Medline
TCR gamma (TRG) chain diversity in splenic gamma delta T cells was determined for ail ego-laying mammal (or monotreme), the duckbill platypus. Three distinct V subgroups were found in the expressed TRG chains and these three subgroups are members of a clade not found so far in eutherian mammals or birds. Each subgroup contains approximately five V gene segments, and their overall divergence is much less than is found in eutherians and birds. consistent with their recent evolution from an ancestral V gene segment. The platypus TRG locus also contains three C region genes and many of the residues involved in TCR function, such as interactions with CD3, were conserved in the monotreme C regions. All non-eutherian mammals (monotremes and marsupials) lacked the second cysteine residue necessary to form the intradomain disulfide bond in the C region, a loss apparently due to independent mutations in marsupials and monotremes. Monotreme TRGC regions also had among the most variation in the length of the connecting peptide region described for any species due to repeated motifs. (c) 2006 Elsevier Ltd. All rights reserved.
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